In partnership with Health Research Group (Australia), Carleton University’s TCIM Lab has been contracted by the World Health Organization (WHO) to carry out an evidence review about epistemology (paradigm)-sensitive research methods in Traditional Medicine (TM). The review aims to: Summarise the scholarly literature on research methods, methodologies, frameworks, and strategies applied in TM research, with an emphasis on issues of epistemology (i.e., diverse knowledge and paradigms/ways of knowing). Explore, characterise, and critically analyse the enablers and barriers for conducting and applying epistemology-sensitive research, including synthetic methods, in TM. Engage with key stakeholders and knowledge users across all global regions to inform the development of epistemology-sensitive methods for research and evidence synthesis in TM. The review is in response to increasing public and political pressure for TM to align with the biomedical evidence-based approach that is widely applied in other areas of health and medicine. However, research methods must also be appropriate for the interventions being studied. TM is often underpinned by traditional/Indigenous knowledges (epistemologies/paradigms) that differ in key ways from biomedicine. As such, biomedical research methods, which are rooted in biomedical epistemologies, are not always optimally suited to studying TM. For more information: https://tcim.carleton.ca/projects/