http://monographs.iarc.fr/ENG/Publications/pub140/IARCpub140.pdf

It addresses the strengths, weaknesses and gaps in the present knowledge on genotoxicity, fibre characterization, cell proliferation and activation, and animal studies, and provides answers to specific questions on the relevance of mechanistic data from in-vitro and in-vivo assays in the assessment of the carcinogenic risk of fibres to humans.