http://www.nap.edu/books/0309089123/html/

.."The purpose of this study was to (1) define the concept of "large-scale science" with respect to cancer research; (2) identify examples of ongoing large-scale projects to determine the current state of the field; (3) identify obstacles to the implementation of large- scale projects in biomedical research; and (4) make recommendations for improving the process for conducting large-scale biomedical science projects, should such projects be undertaken in the future..."(Au) (June 2003)